Edition 25, 2013
Optimum Conditions for Therapeutic Proteins

The Medicine of Giant Molecules

  • Optimum process chain: Jennifer Tummes (left) and Philipp Ehrsam check a pH sensor on the fermenter in which cells produce biologics.
  • Cell expert: before bacteria or mammalian cells end up in a fermenter for the production of drug products, they are first selected for this task in the laboratory by Dr. Beate Müller-Tiemann and then given new properties, optimized for production and further developed.
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Optimum process chain: Jennifer Tummes (left) and Philipp Ehrsam check a pH sensor on the fermenter in which cells produce biologics.

Biologics provide new ways for treating diseases like cancer, inflammation and hemophilia. However, manufacturing the complex protein molecules requires highly specialized process engineering, because only living organisms can produce the complex biomolecules. Bayer researchers are now testing a facility that produces these new bearers of hope in medicine.

For more information on the challenges of biologics production, from genes through to the finished antibody therapy, read here: